Urine microscopy with digital holographic microscopy

Urine microscopy with digital holographic microscopy

Microscopic urine analysis is a key step in diagnosing infections, inflammation, kidney disease and metabolic conditions. It allows clinicians to directly observe cellular and structural components in urine, including red and white blood cells, casts and crystals. By automating this process using digital holography, we help eliminate the need for staining, centrifugation and manual evaluation, making microscopic analysis faster, cleaner and easier to standardize. 

Our DHM module captures high-resolution images of native urine samples, without stains, dyes or physical manipulation. Using AI-based classification, it delivers consistent particle detection in seconds. 

Holographic optics – Interference-based imaging of sample morphology 

AI algorithms – Identify and classify key particle types 

No staining or centrifugation 

Objective classification 

CMOS sensor – Captures detailed sample data digitally 

Quantitative output – Counts and structure information without manual input

Consistent digital imaging

Fully integrable into lab or diagnostic systems

Our module identifies a wide range of particle types typically assessed in urine microscopy. Imaging and classification are performed without the need for staining, calibration or subjective review. 

The current AI model is trained to detect and classify: 

  • Red and white blood cells 
  • Hyaline and granular casts 
  • Crystals (e.g., struvite, calcium oxalate) 
  • Squamous and transitional epithelial cells 

The classification range can be adapted or extended based on specific diagnostic requirements. Whether you need additional structures or new sample types, the underlying pipeline is built to grow with your use case. 

Ephitelial cells & white blood cells
Blood cells & ephitelial cells
Blood cells, ephitelial cells & casts

For technical documentation, OEM integration details or evaluation support, our applications team is here to help.

Marc Althaus
Head of Analyzer and Applications
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